# Machine Learning Directed Discovery and Optimisation of a Platinum-Catalysed Amide Reduction

May 29, 2026

Eleonora Casillo, Benon P. Maliszewski, César A. Urbina-Blanco, Thomas Scattolin, Catherine S. J. Cazin, Steven P. Nolan

Posted in **Chemical Communications** on November 12, 2024

##### **Abstract**

The discovery and optimisation of reaction conditions leading to the reduction of amides, a fundamental large-scale industrial reaction, is achieved using a machine learning (ML) platform and a platinum catalyst. The optimisation leads to the discovery of a new platinum-based catalytic system that displays unexpectedly high performance. The approach enables rapid and high conversions at ppm-level catalyst loadings.

[Click here to read the full article.](https://pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc05273k)

_Casillo, E.; Maliszewski, B.P.; Urbina-Blanco, C.A.; Scattolin, T.; Cazin, C.S.J.; Nolan, S.P. "Machine Learning Directed Discovery and Optimisation of a Platinum-Catalysed Amide Reduction." Chem. Commun., 2024, 60, 14597–14600. https://doi.org/10.1039/D4CC05273K_

© 2024 The Authors. Published by Royal Society of Chemistry. Licensed under CC BY-NC 3.0.